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Article

Janus Kinase 2 Enhances the Stability of the Mature Growth Hormone Receptor

5 Aug 2005

Abstract excerpt

The abundance of surface GH receptor (GHR) is an important determinant of cellular GH sensitivity and is regulated at both transcriptional and posttranscriptional levels. In previous studies of GHR-expressing Janus kinase 2 (JAK2)-deficient human fibrosarcoma cells (gamma2A-GHR), we demonstrated that stable transfection with JAK2 resulted in increased steady-state levels of mature GHR (endoH-resistant; relative...

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Identifiers

PMID: 16081639
DOI: 10.1210/en.2005-0514

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Janus Kinase 2 Enhances the Stability of the Mature Growth Hormone ReceptorPMID 16081639Read ↗

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