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Article

Determinants of growth hormone receptor down-regulation.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2007

Deng Luqin, He Kai, Wang Xiangdong, Yang Ning, Thangavel Chellappagounder, Jiang Jing, Fuchs Serge Y, Frank Stuart J

Abstract excerpt

GH receptor (GHR) is a cytokine receptor family member that responds to GH by activation of the receptor-associated tyrosine kinase, JAK2 (Janus family of tyrosine kinase 2). We previously showed that JAK2, in addition to being a signal transducer, dramatically increases the half-life of mature GHR, partly by preventing constitutive GHR down-regulation. Herein we explored GHR and JAK2 determinants for both...

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Source

Identifiers

PMID: 17488973
DOI: 10.1210/me.2007-0138

Genes

GHR
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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