Article
Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase.
Molecular endocrinology (Baltimore, Md.) - 1 Nov 1996
Yi W, Kim S O, Jiang J, Park S H, Kraft A S, Waxman D J, Frank S J
Abstract excerpt
GH-induced activation of JAK2, a GH receptor (GHR)-associated tyrosine kinase, leads to tyrosine phosphorylation and activation of STATs (signal transducers and activators of transcription) 1, 3, and 5. The present study investigates the importance of the GHR cytoplasmic domain in the activation...
Topics
- Animals
- Binding Sites
- COS Cells
- Cytoplasm
- DNA-Binding Proteins
- Growth Hormone
- Janus Kinase 2
- Milk Proteins
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Rabbits
- Receptors, Somatotropin