Article
Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase.
Molecular endocrinology (Baltimore, Md.) - 1 Nov 1996
Yi W, Kim S O, Jiang J, Park S H, Kraft A S, Waxman D J, Frank S J
Abstract excerpt
GH-induced activation of JAK2, a GH receptor (GHR)-associated tyrosine kinase, leads to tyrosine phosphorylation and activation of STATs (signal transducers and activators of transcription) 1, 3, and 5. The present study investigates the importance of the GHR cytoplasmic domain in the activation of STAT3 and STAT5b. As the perimembranous Box1 region of the GHR cytoplasmic domain is necessary for activation of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.