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Article

A conformationally sensitive GHR [growth hormone (GH) receptor] antibody: impact on GH signaling and GHR proteolysis.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 2004

Jiang Jing, Wang Xiangdong, He Kai, Li Xin, Chen Changmin, Sayeski Peter P, Waters Michael J, Frank Stuart J

Abstract excerpt

The GH receptor (GHR) mediates metabolic and somatogenic actions of GH. Its extracellular domain (ECD; residues 1-246) has two subdomains, each with seven beta strands organized into two antiparallel beta sheets, connected by a short hinge region. Most of the ECD residues involved in GH binding reside in subdomain 1, whereas subdomain 2 harbors a dimerization interface between GHR dimers that alters conformation...

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Source

Identifiers

PMID: 15345746
DOI: 10.1210/me.2004-0102

Genes

GHR
ECD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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