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Article

Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization.

The Journal of biological chemistry - 11 Nov 2005

Landsman Tanya, Waxman David J

Abstract excerpt

The cytokine-inducible SH2 domain-containing protein CIS inhibits signaling from the growth hormone (GH) receptor (GHR) to STAT5b by a proteasome-dependent mechanism. Here, we used the GH-responsive rat liver cell line CWSV-1 to investigate the role of CIS and the proteasome in GH-induced GHR internalization. Cell-surface GHR localization and internalization were monitored in GH-stimulated cells by confocal...

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Share to Endocytosis
Share to Growth Hormone
Share to Immediate-Early Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proteasome Endopeptidase Complex

Share to Receptors, Somatotropin

Share to src Homology Domains

Share to STAT5 Transcription Factor

Share to Suppressor of Cytokine Signaling Proteins

Source

Identifiers

PMID: 16154995
DOI: 10.1074/jbc.M504125200

Genes

GHR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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