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Article

Different configurations of specific thyroid hormone response elements mediate opposite effects of thyroid hormone and GC-1 on gene expression.

Endocrinology - 1 Nov 2005

Gloss Bernd, Giannocco Gisele, Swanson Eric A, Moriscot Anselmo S, Chiellini Grazia, Scanlan Thomas, Baxter John D, Dillmann Wolfgang H

Abstract excerpt

T3 regulates transcription of the rat sarcoendoplasmic reticulum calcium ATPase in the heart. The T3 effect is mediated by three differently configured T3 response elements (TREs). Here we report the mutation of each individual TRE in the promoter and the contribution of each TRE on gene expression. Mutation of TRE1, a direct repeat element, exerted the strongest T3 response, compared with TRE2 and TRE3, which...

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Identifiers

PMID: 16081636
DOI: 10.1210/en.2005-0631

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Source receipt: pubmed, retrieved 7 Sept 2026.

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