Article
Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis.
Arthritis and rheumatism - 1 Jul 2003
Lard L R, van Gaalen F A, Schonkeren J J M, Pieterman E J, Stoeken G, Vos K, Nelissen R G H H, Westendorp R G J, Hoeben R C, Breedveld F C, Toes R E M, Huizinga T W J
Abstract excerpt
OBJECTIVE: To analyze the -2849 A/G interleukin-10 (IL-10) promoter polymorphism, which is associated with high (AG/GG) and low (AA) IL-10 production, in a cohort of rheumatoid arthritis (RA) patients and controls in order to gain a better understanding of its role in the incidence and progression of RA. METHODS: Allele frequencies of the promoter polymorphism -2849 A/G and carriage rates were compared in 283 RA...
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