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Article

Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2001

Gibson A W, Edberg J C, Wu J, Westendorp R G, Huizinga T W, Kimberly R P

Abstract excerpt

Family studies of first-degree relatives and analysis of twins indicate that as much as 75% of the differences in quantitative IL-10 production in man derive from heritable genetic factors. Studies of single nucleotide polymorphisms (SNP) in the proximal 1.0 kb of the IL-10 promoter have yielded inconsistent association with IL-10 production and variable results in promoter-reporter studies. However, in normal...

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PMID: 11238636
DOI: 10.4049/jimmunol.166.6.3915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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