Article
Single nucleotide polymorphisms of Ficolin 2 gene in Behçet's disease.
Journal of dermatological science - 1 Sept 2006
Chen Xixue, Katoh Yasunobu, Nakamura Koichiro, Oyama Noritaka, Kaneko Fumio, Endo Yuichi, Fujita Teizo, Nishida Tomomi, Mizuki Nobuhisa
Abstract excerpt
BACKGROUND: Genetic susceptibility to Behçet's disease (BD) is well documented for HLA-B51 positivity. However, BD is not a simple hereditary disease and it is exaggerated by exogenous stimuli such as microorganisms' infections. Ficolin 2 is a lectin that binds to the surface of microbial cells and kills microbial cells through the activation of complement system. Novel single nucleotide polymorphisms (SNPs) of...
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