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Article

GSK3β N-terminus binding to p53 promotes its acetylation

1 Jan 2009

Abstract excerpt

The prevalence in human cancers of mutations in p53 exemplifies its crucial role as a tumor suppressor transcription factor. Previous studies have shown that the constitutively active serine/threonine kinase glycogen synthase kinase-3beta (GSK3 beta) associates with the C-terminal basic domain of p53 and regulates its actions. In this study we identified the GSK3 beta N-terminal amino acids 78-92 as necessary for...

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PMID: 19265551
DOI: 10.1186/1476-4598-8-14

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