Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression studies of naturally occurring human dopamine transporter variants identifies a novel state of transporter inactivation associated with Val382Ala.

Neuropharmacology - 1 Nov 2005

Mazei-Robison Michelle S, Blakely Randy D

Abstract excerpt

Multiple, rare, human dopamine (DA) transporter (hDAT, SLC6A3) coding variants have been described, though to date they have been incompletely characterized. Here we present studies analyzing the function and regulation of five naturally occurring coding variants, V55A, R237Q, V382A, A559V and E602G, expressed in COS-7 and SH-SY5Y cells. All variants, except V382A, exhibited levels of surface protein expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amphetamine
Share to Biotinylation
Share to Cocaine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine Plasma Membrane Transport Proteins

Share to Dopamine Uptake Inhibitors

Share to Drug Interactions

Share to Norepinephrine

Share to Phorbol Esters

Source

Identifiers

PMID: 16212992
DOI: 10.1016/j.neuropharm.2005.08.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression studies of naturally occurring human dopamine transporter variants identifies a novel state of transporter inactivation associated with Val382Ala.PMID 16212992Read ↗

Human dopamine transporter gene variation: effects of protein coding variants V55A and V382A on expression and uptake activities.Semantic proximity Read ↗

Comparison of the function of two novel human dopamine D2 receptor variants identifies a likely mechanism for their pathogenicity.Semantic proximity Read ↗

Anomalous dopamine release associated with a human dopamine transporter coding variant.Semantic proximity Read ↗

SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking.Semantic proximity Read ↗

Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase.Semantic proximity Read ↗

Characterization of SNPs in the dopamine-β-hydroxylase gene providing new insights into its structure-function relationship.Semantic proximity Read ↗

Thr136Ile polymorphism of human vesicular monoamine transporter-1 (SLC18A1 gene) influences its transport activity in vitro.Semantic proximity Read ↗

Dopamine Transporter Deficiency Syndrome (DTDS): Expanding the Clinical Phenotype and Precision Medicine Approaches.Semantic proximity Read ↗

Leaky lessons learned: Efflux prone dopamine transporter variant reveals sex and circuit specific contributions of D2 receptor signalling to neuropsychiatric diseaseSemantic proximity Read ↗

Functional characterization of human variants of the mu-opioid receptor gene.Semantic proximity Read ↗

Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood.Semantic proximity Read ↗

The dopamine transporter role in psychiatric phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.