Article
Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Nov 2005
Masternak Michal M, Al-Regaiey Khalid A, Del Rosario Lim Marc Michael, Jimenez-Ortega Vanesa, Panici Jacob A, Bonkowski Michael S, Kopchick John J, Bartke Andrzej
Abstract excerpt
Growth hormone receptor/binding protein knockout (GHR-KO) mice live approximately 40% longer than their normal siblings do. These mice have dramatically reduced plasma levels of insulin-like growth factor 1 (IGF1) and enhanced insulin sensitivity. We examined the expression level of peroxisome proliferator-activated receptors (PPARs) and retinoid X receptors family genes in the livers of normal and GHR-KO mice...
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