Calorie restriction in humans inhibits the <scp>PI</scp>3<scp>K</scp>/<scp>AKT</scp> pathway and induces a younger transcription profile

Abstract excerpt

Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust interventions known to increase longevity in lower organisms. However, little is known about the molecular adaptations induced by CR in humans. Here, we report that long-term CR in humans inhibits the IGF-1/insulin pathway in skeletal muscle, a key metabolic tissue. We also demonstrate that CR induces dramatic changes of...

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