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Article

Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat.

Annals of the New York Academy of Sciences - 1 Jun 2004

Zhu Min, de Cabo Rafael, Lane Mark A, Ingram Donald K

Abstract excerpt

Mutations that extend life span in C. elegans suggest that the insulin/IGF-1 signaling (IS) pathway may play a key role in retarding aging and extending life span by caloric restriction (CR). To evaluate this hypothesis, male rats were subjected to either AL (ad libitum) or CR (40% from AL) for 2 and 25 months, and then the effects of CR on the early events in the IS pathway in liver and muscle were assessed. The...

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PMID: 15247064
DOI: 10.1196/annals.1297.082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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