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Article

Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice.

Experimental gerontology - 1 Oct 2014

Gesing Adam, Al-Regaiey Khalid A, Bartke Andrzej, Masternak Michal M

Abstract excerpt

Disruption of the growth hormone (GH) axis promotes longevity and delays aging. In contrast, GH over-expression may lead to accelerated aging and shorter life. Calorie restriction (CR) improves insulin sensitivity and may extend lifespan. Long-lived Ames dwarf (df/df) mice have additional extension of longevity when subjected to 30% CR. The aim of the study was to assess effects of CR or GH replacement therapy...

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Source

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Identifiers

PMID: 25152388
DOI: 10.1016/j.exger.2014.08.010
PMCID: PMC4252511

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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