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Article

Nucleophosmin mutations confer an independent favorable prognostic impact in 869 pediatric patients with acute myeloid leukemia.

Blood cancer journal - 9 Jan 2020

Xu Lu-Hong, Fang Jian-Pei, Liu Yao-Chung, Jones Adrianna I, Chai Li

Abstract excerpt

Studies on the clinical significance of Nucleophosmin (NPM1) mutations in pediatric AML in a large cohort are lacking. Moreover, the prognosis of patients with co-occurring NPM1 and FLT3/ITD mutations is controversial. Here, we analyzed the impact of NPM1 mutations on prognoses of 869 pediatric AML patients from the TAGET dataset. The frequency of NPM1 mutations was 7.6%. NPM1 mutations were significantly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31915364
DOI: 10.1038/s41408-019-0268-7
PMCID: PMC6949268

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