Article

Prognostic impact of age and MDS-associated mutations in <i>NPM1</i> -mutated AML

2025-11-06

Abstract excerpt

Nucleophosmin-1 ( NPM1 ) mutations define a major molecular subtype of acute myeloid leukemia (AML) and is generally associated with favorable prognosis. However, the impact of myelodysplasia-associated mutations (MDSm+) on patient outcomes within this subgroup remains uncertain. We retrospectively analyzed 271 NPM1 -mutated AML patients from three independent cohorts (SWOG, Fred Hutch, and Beat AML) to assess t...

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Literature Corpus work: c6e388e8-4826-59ce-89a6-71cc0d3a40c2
DOI: 10.1101/2025.11.03.25339099

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