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Article

Effects of mutant human Ki-ras(G12C) gene dosage on murine lung tumorigenesis and signaling to its downstream effectors.

Toxicology and applied pharmacology - 15 Aug 2008

Dance-Barnes Stephanie T, Kock Nancy D, Floyd Heather S, Moore Joseph E, Mosley Libyadda J, D'Agostino Ralph B, Pettenati Mark J, Miller Mark Steven

Abstract excerpt

Studies in cell culture have suggested that the level of RAS expression can influence the transformation of cells and the signaling pathways stimulated by mutant RAS expression. However, the levels of RAS expression in vivo appear to be subject to feedback regulation, limiting the total amount of RAS protein that can be expressed. We utilized a bitransgenic mouse lung tumor model that expressed the human...

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Identifiers

PMID: 18565564
DOI: 10.1016/j.taap.2008.04.014
PMCID: PMC2596665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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