Article
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis.
Cell - 29 Jul 2005
Giorgio Marco, Migliaccio Enrica, Orsini Francesca, Paolucci Demis, Moroni Maurizio, Contursi Cristina, Pelliccia Giovanni, Luzi Lucilla, Minucci Saverio, Marcaccio Massimo, Pinton Paolo, Rizzuto Rosario, Bernardi Paolo, Paolucci Francesco, Pelicci Pier Giuseppe
Abstract excerpt
Reactive oxygen species (ROS) are potent inducers of oxidative damage and have been implicated in the regulation of specific cellular functions, including apoptosis. Mitochondrial ROS increase markedly after proapoptotic signals, though the biological significance and the underlying molecular mechanisms remain undetermined. P66Shc is a genetic determinant of life span in mammals, which regulates ROS metabolism...
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