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Article

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway.

Science (New York, N.Y.) - 29 Mar 2002

Nemoto Shino, Finkel Toren

Abstract excerpt

Genetic determinants of longevity include the forkhead-related transcription factor DAF-16 in the worm Caenorhabditis elegans and the p66shc locus in mice. We demonstrate that p66shc regulates intracellular oxidant levels in mammalian cells and that hydrogen peroxide can negatively regulate forkhead activity. In p66shc-/- cells, the activity of the mammalian forkhead homolog FKHRL1 is increased and...

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PMID: 11884717
DOI: 10.1126/science.1069004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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