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Article

The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism.

The Journal of biological chemistry - 14 Apr 2006

Nemoto Shino, Combs Christian A, French Stephanie, Ahn Bong-Hyun, Fergusson Maria M, Balaban Robert S, Finkel Toren

Abstract excerpt

Previous studies have determined that mice with a homozygous deletion in the adapter protein p66(shc) have an extended life span and that cells derived from these mice exhibit lower levels of reactive oxygen species. Here we demonstrate that a fraction of p66(shc) localizes to the mitochondria and that p66(shc-/-) fibroblasts have altered mitochondrial energetics. In particular, despite similar cytochrome...

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Identifiers

PMID: 16481327
DOI: 10.1074/jbc.M511626200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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