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Article

P66SHC and Ageing: ROS and TOR?

28 Jul 2010

Abstract excerpt

Both Reactive Oxygen Species (ROS) and hyperactivation of the nutrient-sensing mTOR/S6 kinase cascade have been linked to aging and age-related diseases as well as to the anti-aging effect of calorie restriction. Recent findings that the pro-aging and pro-oxidant molecule p66shc contributes to S6K activation by nutrients and promotes insulin resistance and diabetes in mice may provide an answer to the "ROS or...

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Identifiers

PMID: 20689155
DOI: 10.18632/aging.100182

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