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Article

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.

Science (New York, N.Y.) - 2 Feb 2007

Pinton Paolo, Rimessi Alessandro, Marchi Saverio, Orsini Francesca, Migliaccio Enrica, Giorgio Marco, Contursi Cristina, Minucci Saverio, Mantovani Fiamma, Wieckowski Mariusz R, Del Sal Giannino, Pelicci Pier Giuseppe, Rizzuto Rosario

Abstract excerpt

The 66-kilodalton isoform of the growth factor adapter Shc (p66Shc) translates oxidative damage into cell death by acting as reactive oxygen species (ROS) producer within mitochondria. However, the signaling link between cellular stress and mitochondrial proapoptotic activity of p66Shc was not known. We demonstrate that protein kinase C beta, activated by oxidative conditions in the cell, induces phosphorylation...

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PMID: 17272725
DOI: 10.1126/science.1135380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.PMID 17272725Read ↗

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