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Article

Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands).

Cancer causes & control : CCC - 1 Aug 2005

van der Hel Olga L, Bueno-de-Mesquita H Bas, van Gils Carla H, Roest Mark, Slothouber Barbara, Grobbee Diederick E, Peeters Petra H M

Abstract excerpt

Variants in the metabolic genes NAT1, NAT2, GSTM1 or GSTT1, may cause differences in individual detoxifying capacity of possible carcinogens. We examined the cumulative effect of putative at risk genotypes on breast cancer risk and we examined the extent to which these polymorphisms modify the association between smoking and breast cancer. A case cohort study was conducted in the DOM cohort with 676 breast cancer...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16049806
DOI: 10.1007/s10552-005-1227-0

Genes

GSTT1
GSTM1
NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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