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Article

NAT2 slow acetylation and GSTM1 null genotypes may increase postmenopausal breast cancer risk in long-term smoking women.

Pharmacogenetics - 1 Jul 2003

van der Hel Olga L, Peeters Petra H M, Hein David W, Doll Mark A, Grobbee Diederick E, Kromhout Daan, Bueno de Mesquita H Bas

Abstract excerpt

N-acetyltransferase (NAT) 1 and 2 and glutathione S-transferase (GST) M1 and T1 are phase II enzymes that are important for activation and detoxification of carcinogenic heterocyclic and aromatic amines, as present in cigarette smoke. We studied whether genetic polymorphisms in these genes modifies the relationship between smoking and breast cancer. A nested case-control study was conducted among participants in...

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Source

Identifiers

PMID: 12835615
DOI: 10.1097/00008571-200307000-00005

Genes

NAT2
GSTM1
GSTT1
NAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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