GSTM1 and GSTT1 polymorphisms and postmenopausal breast cancer risk.

Abstract excerpt

Glutathione S-transferases (GSTs) are a family of important enzymes involved in the detoxification of a wide variety of known and suspected carcinogens, including potential mammary carcinogens identified in charred meats and tobacco smoke. A substantial proportion of the Caucasian population has a homozygous deletion (null) of the GSTMI or GSTT1 gene, which results in lack of production of these isoenzymes. We...

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