Article
Cigarette smoking, glutathione-s-transferase M1 and t1 genetic polymorphisms, and breast cancer risk (United States).
Cancer causes & control : CCC - 1 Sept 2002
Zheng Tongzhang, Holford Theodore R, Zahm Shelia H, Owens Patricia H, Boyle Peter, Zhang Yawei, Wise John Pierce, Stephenson Lisa Pleasants, Ali-Osman Francis
Abstract excerpt
OBJECTIVE: It has been suggested that functional polymorphisms in genes encoding tobacco carcinogen-metabolizing enzymes may modify the relationship between tobacco smoking and breast cancer risk. We sought to determine if there is a gene-environment interaction between GSTM I (GSTM1A and GSTM1B), and GSTT1 genotypes and cigarette smoking in the risk of breast cancer. METHODS: Cases and controls were recruited in...
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