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Article

The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism.

The Journal of biological chemistry - 14 Oct 2005

Gianni Stefano, Engström Ake, Larsson Mårten, Calosci Nicoletta, Malatesta Francesco, Eklund Lars, Ngang Chi Celestine, Travaglini-Allocatelli Carlo, Jemth Per

Abstract excerpt

PDZ domains are protein adapter modules present in a few hundred human proteins. They play important roles in scaffolding and signal transduction. PDZ domains usually bind to the C termini of their target proteins. To assess the binding mechanism of this interaction we have performed the first in-solution kinetic study for PDZ domains and peptides corresponding to target ligands. Both PDZ3 from postsynaptic...

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Identifiers

PMID: 16049001
DOI: 10.1074/jbc.M506017200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism.PMID 16049001Read ↗

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