Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains.

Scientific reports - 11 Aug 2017

Caillet-Saguy Célia, Toto Angelo, Guerois Raphael, Maisonneuve Pierre, di Silvio Eva, Sawyer Kristi, Gianni Stefano, Wolff Nicolas

Abstract excerpt

Human protein tyrosine phosphatase non-receptor type 4 (PTPN4) has been shown to prevent cell death. The active form of human PTPN4 consists of two globular domains, a PDZ (PSD-95/Dlg/ZO-1) domain and a phosphatase domain, tethered by a flexible linker. Targeting its PDZ domain abrogates this protection and triggers apoptosis. We previously demonstrated that the PDZ domain inhibits the phosphatase activity of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Biocatalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kinetics

Share to Ligands

Share to PDZ Domains

Share to Phosphoric Monoester Hydrolases

Share to Proteolysis

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 28801650
DOI: 10.1038/s41598-017-08193-6
PMCID: PMC5554198

Genes

PTPN4
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains.PMID 28801650Read ↗

The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism.Semantic proximity Read ↗

Structural basis of the auto-inhibition mechanism of nonreceptor tyrosine kinase PTK6.Semantic proximity Read ↗

Interactions of native peptides and small molecules with the PDZ domains of PSD-95 and SAP97Semantic proximity Read ↗

Inter-domain interactions influence the stability and catalytic activity of the bi-domain protein tyrosine phosphatase PTP99A.Semantic proximity Read ↗

Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.Semantic proximity Read ↗

Evaluation of energetic and dynamic coupling networks in a PDZ domain protein.Semantic proximity Read ↗

Integrative structural modeling of a multidomain polo-like kinase.Semantic proximity Read ↗

Post-translational modifications modulate ligand recognition by the third PDZ domain of the MAGUK protein PSD-95.Semantic proximity Read ↗

Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains.Semantic proximity Read ↗

Formation of nNOS/PSD-95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain.Semantic proximity Read ↗

New insights into Dok-4 PTB domain structure and function.Semantic proximity Read ↗

The linker pivot in Ci-VSP: the key to unlock catalysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.