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Article

Two conserved residues govern the salt and pH dependencies of the binding reaction of a PDZ domain.

The Journal of biological chemistry - 1 Dec 2006

Chi Celestine N, Engström Ake, Gianni Stefano, Larsson Mårten, Jemth Per

Abstract excerpt

PDZ domains are protein-protein interaction modules found in hundreds of human proteins. Their binding reactions are sensitive to variations in salt and pH but the basis of the respective dependence has not been clear. We investigated the binding reaction between PSD-95 PDZ3 and a peptide corresponding to a native ligand with protein engineering in conjunction with stopped-flow and equilibrium fluorimetry and...

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Identifiers

PMID: 17018532
DOI: 10.1074/jbc.M607883200

Genes

PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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