Article
Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men.
The Journal of nutrition - 1 Aug 2005
Lim Unhee, Peng Kun, Shane Barry, Stover Patrick J, Litonjua Augusto A, Weiss Scott T, Gaziano J Michael, Strawderman Robert L, Raiszadeh Farbod, Selhub Jacob, Tucker Katherine L, Cassano Patricia A
Abstract excerpt
Genetic variation in folate-regulating enzymes contributes to the risk of cardiovascular disease (CVD). The cytoplasmic serine hydroxymethyltransferase (cSHMT) enzyme is proposed to regulate a key metabolic intersection in folate metabolism. We hypothesized that a variant in cSHMT (cSHMT 1420C-->T) affects CVD risk, and that the effect depends on a linked step in the metabolic pathway catalyzed by...
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