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Article

Homocysteine levels and cancer risk in hypertensive adults across MTHFR C677T genotypes.

Scientific reports - 4 Feb 2026

Li Wenqiang, Xu Guoshuai, Yang Lin, Song Yun, Chen Ping, Liu Lishun, Qu Jun, Wang Binyan

Abstract excerpt

Metabolic factors, such as homocysteine (Hcy) metabolism, are believed to influence cancer risk. The MTHFR C677T polymorphism, which raises Hcy levels by affecting folate metabolism, has been associated with varying cancer risks. However, previous studies have not fully explored the interaction between Hcy levels and MTHFR C677T genotypes in relation to cancer risk. This nested case-control study within the China...

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Identifiers

PMID: 41634286
DOI: 10.1038/s41598-026-37849-5
PMCID: PMC12923864

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MTHFR

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