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Article

The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway.

QJM : monthly journal of the Association of Physicians - 1 Aug 2007

Siva A, De Lange M, Clayton D, Monteith S, Spector T, Brown M J

Abstract excerpt

BACKGROUND: The extent of genetic influence on plasma homocysteine, a risk factor for ischaemic heart disease, is uncertain. Many association studies have investigated common polymorphisms and their role in hyperhomocysteinaemia, but only the thermolabile variant of methylene tetrahydrofolate reductase (MTHFR) has shown an association (small but robust). AIM: To estimate the heritability of plasma homocysteine...

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Source

Identifiers

PMID: 17636160
DOI: 10.1093/qjmed/hcm054

Genes

MTHFR
MTRR
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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