Methylenetetrahydrofolate Reductase C677T Polymorphism, Venous Thrombosis, Cardiovascular Risk, and Other Effects

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) plays a major role in regulating levels of homocysteine (HC), and the C677T mutation of this enzyme results in significantly decreased activity. This MTHFR C677T genotype is associated with elevated plasma HC and an increased risk of cardiovascular (CV) disease. The HC levels are set by individual laboratories, but in general, a level 60 mmol/L (808 mg/dL) considered...