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Genetic and pharmacological inactivation of adenosine A2A receptor reveals an Egr-2-mediated transcriptional regulatory network in the mouse striatum.

Physiological genomics - 21 Sept 2005

Yu Liqun, Haverty Peter M, Mariani Juliana, Wang Yumei, Shen Hai-Ying, Schwarzschild Michael A, Weng Zhiping, Chen Jiang-Fan

Abstract excerpt

The adenosine A2A receptor (A2AR) is highly expressed in the striatum, where it modulates motor and emotional behaviors. We used both microarray and bioinformatics analyses to compare gene expression profiles by genetic and pharmacological inactivation of A2AR and inferred an A2AR-controlled transcription network in the mouse striatum. A comparison between vehicle (VEH)-treated A2AR knockout (KO) mice (A2AR...

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PMID: 16046619
DOI: 10.1152/physiolgenomics.00068.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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