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Article

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

15 Aug 2002

Abstract excerpt

Previous analyses of gene expression in a mouse model of Huntington's disease (R6/2) indicated that an N-terminal fragment of mutant huntingtin causes downregulation of striatal signaling genes and particularly those normally induced by cAMP and retinoic acid. The present study expands the regional and temporal scope of this previous work by assessing whether similar changes occur in other brain regions affected...

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PMID: 12165554
DOI: 10.1093/hmg/11.17.1911

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Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brainPMID 12165554Read ↗

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