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On the Role of Adenosine A2A Receptor Gene Transcriptional Regulation in Parkinson’s Disease

10 Jul 2019

Abstract excerpt

Adenosine A2A receptors (A2ARs) have attracted considerable attention as an important molecular target for the design of Parkinson's disease (PD) therapeutic compounds. Here, we studied the transcriptional regulation of the A2AR gene in human peripheral blood mononuclear cells (PBMCs) obtained from PD patients and in the striatum of the well-validated, 6-hydroxydopamine (6-OHDA)-induced PD mouse model. We report...

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PMID: 31354407
DOI: 10.3389/fnins.2019.00683

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