Article
Pathophysiology, pleiotrophy and paradigm shifts: genetic lessons from Parkinson's disease.
Biochemical Society transactions - 1 Aug 2005
Ross O A, Farrer M J
Abstract excerpt
PD (Parkinson's disease) is an aetiologically heterogeneous disorder characterized by a clinical phenotype consisting of resting tremor, rigidity and bradykinesia. Motor symptoms are associated with a progressive loss of dopaminergic neurons, with Lewy body inclusions within surviving neurons. Although heritability studies have shown evidence of familial aggregation, twin studies have provided limited support for...
Topics
- Humans
- Models, Molecular
- Models, Neurological
- Mutation
- Nerve Tissue Proteins
- Parkinson Disease
- Protein Conformation
- Ubiquitin-Protein Ligases