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Article

Opposing effects of CXCR3 and CCR5 deficiency on CD8+ T cell-mediated inflammation in the central nervous system of virus-infected mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2005

de Lemos Carina, Christensen Jeanette Erbo, Nansen Anneline, Moos Torben, Lu Bao, Gerard Craig, Christensen Jan Pravsgaard, Thomsen Allan Randrup

Abstract excerpt

T cells play a key role in the control of viral infection in the CNS but may also contribute to immune-mediated cell damage. To study the redundancy of the chemokine receptors CXCR3 and CCR5 in regulating virus-induced CD8+ T cell-mediated inflammation in the brain, CXCR3/CCR5 double-deficient mice were generated and infected intracerebrally with noncytolytic lymphocytic choriomeningitis virus. Because these...

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Source

Identifiers

PMID: 16034118
DOI: 10.4049/jimmunol.175.3.1767

Genes

CXCR3
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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