Article
Both CXCR3 and CXCL10/IFN-inducible protein 10 are required for resistance to primary infection by dengue virus.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2006
Hsieh Ming-Fang, Lai Szu-Liang, Chen Jia-Perng, Sung Jui-Ming, Lin Yi-Ling, Wu-Hsieh Betty A, Gerard Craig, Luster Andrew, Liao Fang
Abstract excerpt
We examined the extent to which CXCR3 mediates resistance to dengue infection. Following intracerebral infection with dengue virus, CXCR3-deficient (CXCR3(-/-)) mice showed significantly higher mortality rates than wild-type (WT) mice; moreover, surviving CXCR3(-/-) mice, but not WT mice, often developed severe hind-limb paralysis. The brains of CXCR3(-/-) mice showed higher viral loads than those of WT mice, and...
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