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Neuronal CXCL10 Directs CD8 <sup>+</sup> T-Cell Recruitment and Control of West Nile Virus Encephalitis

15 Aug 2005

Abstract excerpt

The activation and entry of antigen-specific CD8(+) T cells into the central nervous system is an essential step towards clearance of West Nile virus (WNV) from infected neurons. The molecular signals responsible for the directed migration of virus-specific T cells and their cellular sources are presently unknown. Here we demonstrate that in response to WNV infection, neurons secrete the chemokine CXCL10, which...

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PMID: 16103196
DOI: 10.1128/jvi.79.17.11457-11466.2005

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