Article
Efficient T-cell surveillance of the CNS requires expression of the CXC chemokine receptor 3.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 May 2004
Christensen Jeanette Erbo, Nansen Anneline, Moos Torben, Lu Bao, Gerard Craig, Christensen Jan Pravsgaard, Thomsen Allan Randrup
Abstract excerpt
T-cells play an important role in controlling viral infections inside the CNS. To study the role of the chemokine receptor CXCR3 in the migration and positioning of virus-specific effector T-cells within the brain, CXCR3-deficient mice were infected intracerebrally with lymphocytic choriomeningitis virus (LCMV). Analysis of the induction phase of the antiviral CD8+ T-cell response did not reveal any immune...
Topics
- Animals
- Biomarkers
- Brain
- CD8-Positive T-Lymphocytes
- Cell Count
- Cell Movement
- Central Nervous System
- Flow Cytometry
- Genetic Predisposition to Disease
- Hyaluronan Receptors
- Immunologic Surveillance
- Leukocytes, Mononuclear