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Inflammation associated with monocyte/macrophage activation and recruitment corresponds with lethal outcome in a mouse model of Crimean-Congo haemorrhagic fever

8 Nov 2024

Abstract excerpt

Crimean-Congo hemorrhagic fever virus (CCHFV) causes human disease ranging from subclinical to a fatal hemorrhagic syndrome. Determinants of CCHF pathogenesis are largely unknown and animal models that recapitulate human disease are limited. A recently described mouse model uses a monoclonal antibody (mAb 5A3) targeting the interferon (IFN) alpha/beta receptor to suppress type I IFN responses, making animals...

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PMID: 39513496
DOI: 10.1080/22221751.2024.2427782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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