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Article

Opposing roles for CXCR3 signaling in central nervous system versus ocular inflammation mediated by the astrocyte-targeted production of IL-12.

The American journal of pathology - 1 Nov 2011

Krauthausen Marius, Ellis Sally L, Zimmermann Julian, Sarris Maria, Wakefield Denis, Heneka Michael T, Campbell Iain L, Müller Marcus

Abstract excerpt

CXCR3 and its ligands are important for the trafficking of activated CD4(+) T(H)1 T cells, CD8(+) T cells, and natural killer cells during inflammation. Recent functional studies demonstrate a more diverse role of CXCR3 in inflammatory diseases of the central nervous system (CNS). We examined the impact of CXCR3 on a less complex interferon-γ-dependent, type 1 cell-mediated immune response in the CNS, induced in...

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Source

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Identifiers

PMID: 21925471
DOI: 10.1016/j.ajpath.2011.07.041
PMCID: PMC3204010

Genes

CXCR3
CCL5
CXCL10
CXCL9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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