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Article

Potentially functional polymorphisms in the ERCC2 gene and risk of esophageal squamous cell carcinoma in Chinese populations.

Scientific reports - 11 Sept 2014

Zhu Mei-Ling, He Jing, Wang MengYun, Sun Meng-Hong, Jin Li, Wang Xiaofeng, Yang Ya-Jun, Wang Jiu-Cun, Zheng Leizhen, Xiang Jia-Qing, Wei Qing-Yi

Abstract excerpt

ERCC2 is indispensable for nucleotide excision repair pathway, and its functional polymorphisms may be associated with cancer risk. In a large case-control study of 1126 esophageal squamous cell carcinomas (ESCC) patients and 1131 controls, we genotyped two SNPs in ERCC2 (rs238406 G > T and rs13181 T > G) and assessed their associations with ESCC risk. We found a significantly elevated ESCC risk associated with...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25209371
DOI: 10.1038/srep06281
PMCID: PMC4160711

Genes

ERCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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