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Article

Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction.

Pharmacogenetics - 1 May 2003

Naber Christoph K, Baumgart Dietrich, Heusch Gerd, Siffert Winfried, Oldenburg Olaf, Huesing Johannes, Erbel Raimund

Abstract excerpt

The 825T allele of a polymorphism at GNB3, encoding the G protein beta(3) subunit, is associated with an enhanced coronary blood flow (CBF) reduction in response to alpha(2)-, but not to alpha(1)-adrenoceptor activation. Because the regulation of vascular tone by alpha(2)-adrenoceptors includes direct vasoconstriction as well as vasodilatation by endothelial release of nitric oxide, the eNOS Glu298Asp variant...

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Source

Identifiers

PMID: 12724620
DOI: 10.1097/00008571-200305000-00007

Genes

GNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction.PMID 12724620Read ↗

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Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation.Semantic proximity Read ↗

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Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit.Semantic proximity Read ↗

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Association between the Glu298Asp and 4b/4a polymorphisms of endothelial nitric oxide synthase and coronary slow flow in the North Indian population.Semantic proximity Read ↗

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The C825T polymorphism of the G-protein β3 subunit gene and its association with hypertension and stroke: an updated meta-analysis.Semantic proximity Read ↗

The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14,094 cases and 17,760 controls.Semantic proximity Read ↗

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