Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The T-786-->C mutation in endothelial nitric oxide synthase is associated with hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Apr 2002

Hyndman Matthew E, Parsons Howard G, Verma Subodh, Bridge Peter J, Edworthy Steven, Jones Charlotte, Lonn Eva, Charbonneau Francois, Anderson Todd J

Abstract excerpt

Although the pathogenic mechanisms involved in predisposing individuals to hypertension are not well defined, evidence is accumulating that suggests a strong genetic transmission. Animal studies and some clinical investigations have revealed that aberrant NO production may be an important contributing factor. Indeed, a missense mutation in the endothelial NO gene caused by a Glu298Asp alteration has been strongly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Hypertension

Share to Nitric Oxide Synthase

Share to Nitric Oxide Synthase Type III

Share to Point Mutation

Source

Identifiers

PMID: 11967250
DOI: 10.1161/01.hyp.0000013703.07316.7f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The T-786-->C mutation in endothelial nitric oxide synthase is associated with hypertension.PMID 11967250Read ↗

Lack of association between T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and essential hypertension.Semantic proximity Read ↗

Endothelial nitric oxide synthase gene single nucleotide polymorphisms and the risk of hypertension: A meta-analysis involving 63,258 subjects.Semantic proximity Read ↗

A T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and coronary arterial vasomotility.Semantic proximity Read ↗

T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm.Semantic proximity Read ↗

Endothelial nitric oxide synthase gene is positively associated with essential hypertension.Semantic proximity Read ↗

Genetic risk factors for coronary artery spasm: significance of endothelial nitric oxide synthase gene T-786-->C and missense Glu298Asp variants.Semantic proximity Read ↗

T-786C variation in the promoter sequence of human eNOS gene markedly influences its expression level.Semantic proximity Read ↗

Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: The Suita Study.Semantic proximity Read ↗

Synergistic interaction of T-786-->C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasm.Semantic proximity Read ↗

Association between the - 786T>C 1polymorphism in the promoter region of endothelial nitric oxide synthase (eNOS) and risk of coronary artery disease: a systematic review and meta-analysis.Semantic proximity Read ↗

T-786C polymorphism in the endothelial nitric oxide synthase gene is associated with increased risk of coronary artery disease in a Chinese population.Semantic proximity Read ↗

T(-786)--> C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.