Article
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia.
Blood - 1 Nov 2005
Xu Rongzhen, Yu Yingzi, Zheng Shu, Zhao Xiaoying, Dong Qinghua, He Zhiwen, Liang Yun, Lu Qinghua, Fang Yongmin, Gan Xiaoxian, Xu Xiaohua, Zhang Suzhan, Dong Qi, Zhang Xiaohong, Feng Gen-Sheng
Abstract excerpt
Shp2 tyrosine phosphatase plays a critical role in hematopoiesis, and dominant active mutations have been detected in the human gene PTPN11, encoding Shp2, in child leukemia patients. We report here that although no such mutations were detected in 44 adult leukemia patients screened, Shp2 expression levels were significantly elevated in primary leukemia cells and leukemia cell lines, as compared with normal...
Topics
- Adolescent
- Adult
- Aged
- Cell Differentiation
- Cell Proliferation
- Cell Transformation, Neoplastic
- Down-Regulation
- Gene Expression Regulation, Neoplastic
- Humans
- Intracellular Signaling Peptides and Proteins