Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.

Leukemia - 1 Jun 2015

Chen L, Chen W, Mysliwski M, Serio J, Ropa J, Abulwerdi F A, Chan R J, Patel J P, Tallman M S, Paietta E, Melnick A, Levine R L, Abdel-Wahab O, Nikolovska-Coleska Z, Muntean A G

Abstract excerpt

PTPN11 encodes the Shp2 non-receptor protein-tyrosine phosphatase implicated in several signaling pathways. Activating mutations in Shp2 are commonly associated with juvenile myelomonocytic leukemia but are not as well defined in other neoplasms. Here we report that Shp2 mutations occur in human acute myeloid leukemia (AML) at a rate of 6.6% (6/91) in the ECOG E1900 data set. We examined the role of mutated Shp2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Clinical Trials, Phase III as Topic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-3

Share to Myeloid Cell Leukemia Sequence 1 Protein

Share to Neoplastic Stem Cells

Share to Oncogene Proteins, Fusion

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 25650089
DOI: 10.1038/leu.2015.18
PMCID: PMC4456293

Genes

MCL1
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.PMID 25650089Read ↗

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.Semantic proximity Read ↗

Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.Semantic proximity Read ↗

SHP-2 and myeloid malignancies.Semantic proximity Read ↗

Innate immune mechanisms hijacked by leukemia-initiating stem cells for selective advantage and immune evasion in Ptpn11-associated JMML.Semantic proximity Read ↗

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.Semantic proximity Read ↗

Shp2 function in hematopoietic stem cell biology and leukemogenesisSemantic proximity Read ↗

JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model.Semantic proximity Read ↗

Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defectsSemantic proximity Read ↗

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.Semantic proximity Read ↗

SHP2 inhibition reduces leukemogenesis in models of combined genetic and epigenetic mutations.Semantic proximity Read ↗

Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemiaSemantic proximity Read ↗

Sunitinib selectively targets leukemogenic signaling of mutant SHP2 in juvenile myelomonocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.