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Article

Shp2 function in hematopoietic stem cell biology and leukemogenesis

13 Apr 2012

Abstract excerpt

PURPOSE OF REVIEW: The protein tyrosine phosphatase Shp2 is encoded by PTPN11 and positively regulates physiologic hematopoiesis. Mutations of PTPN11 cause the congenital disorder Noonan syndrome and pathologically promote human leukemias. Given the high frequency of PTPN11 mutations in human disease, several animal models have been generated to investigate Shp2 in hematopoietic stem cell (HSC) function and...

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PMID: 22504523
DOI: 10.1097/moh.0b013e328353c6bf

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